DIATRAK

Development of a innovative technology for the diagnosis of TSH-Rezeptor dependent autoimmune diseases

The DIATRAK project was granted by the german authorties within the initiative BioChance plus and was aimed to establish novel innovative solutions for the diagnosis of TSH-Receptor based autoimmune diseases. Within this project MicroMol succeeded to establish a series of functional active recombinant proteins spanning various parts of the extracellular domain of the human TSH Receptor. On the basis of these TSHR variants MicroMol established a test system with which it was possible to determine anti TSHR reactivity from the serum of patients suffering on thyroid autoimmune disease. During the course of this project MicroMol implemented a platform technology for the identification of immunological relevant protein epitopes and succeded to determine the physiological relevant epitopes of the human TSH Receptor. Theses autoepitopes will be the basis for a TSHR based differential diagnostic system.

THERATRAK

Functional evaluation of autoantibody epitopes of the human TSH-Receptor as the basis for a novel therapeutical approach for the treatment of autoimmune diseases of the thyroid

The THERATRAK project – which is also granted within the BioChancePlus initiative - is the consequent follow up scheme of the DIATRAK project . During this project MicroMol will create functional active cell lines expressing the complete human TSH-Receptor as well as variants thereof. These TSHR transfectants will be tools to analyze the ability of the identified peptides to interfere in the function of TSHR specific autoantibodies present in the serum of patients suffering on thyroid autoimmune disease. In addition to that MicroMol will investigate the function of TSHR specific autoreactive T-cell clones. The results of the THERATRAK studies will give ideas and solutions for novel therapeutic approaches with the aim of replacing the up to now extremely aggressive therapies of thyroid autoimmune disease.

ALLERGOSCAN

Development of a higly specific method for the determination of hidden food allergens 

The AllergoScan project fits perfectly well in the MicroMols concept dealing with abnormalities of the human immune system. The concept is granted by the initiative Biotechnology Baden Württemberg with the aim to establish highly sensitive and specific approaches for the determination of hidden allergens in a defined food sample but also directly in the production line of food producing facilities. In contrast to existing test system AllergoScan determines the minimal allergy inducing entity – the allergenic epitope - and therefore will be able to determine a defined allergen with extremely high specifity. In combination with novel immunological labeling approaches the concept will end up in a series of allergen specific DipSticks with the abilty to define the allergen directly at the place of action.

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